>> << >>
Главная Выпуск 31 NewConcepts Chapters
Life Science and Technologies

Cancer can be precisely diagnosed using a urine test with artificial intelligence

by National Research Council of Science & Technology
Январь 2021



Cancer can be precisely diagnosed using a urine test with artificial intelligence
The set of sensing signals collected for each patient were then analyzed using ML to screen the patient for PCa. Seventy-six urine samples were measured three times, thereby generating 912 biomarker signals or 228 sets of sensing signals. We used RF and NN algorithms to analyze the multimarker signals. Both algorithms provided an increased accuracy, and the AUROC increased in size as the number of biomarkers was increased. Credit: Korea Institute of Science and Technology (KIST)

Prostate cancer is one of the most common cancers among men. Patients are determined to have prostate cancer primarily based on PSA, a cancer factor in blood. However, as diagnostic accuracy is as low as 30%, a considerable number of patients undergo additional invasive biopsy and thus suffer from resultant side effects, such as bleeding and pain.

The Korea Institute of Science and Technology (KIST) announced that the collaborative research team led by Dr. Kwan Hyi Lee from the Biomaterials Research Center and Professor In Gab Jeong from Asan Medical Center developed a technique for diagnosing  from  within only 20 minutes with almost 100% accuracy. The research team developed this technique by introducing a smart AI analysis method to an electrical-signal-based ultrasensitive biosensor.

As a noninvasive method, a  using urine is convenient for patients and does not need invasive biopsy, thereby diagnosing  without side effects. However, as the concentration of cancer factors is low in urine, urine-based biosensors are only used for classifying risk groups rather than for precise diagnosis thus far.

Dr. Lee's team at the KIST has been working toward developing a technique for diagnosing disease from urine with an electrical-signal-based ultrasensitive biosensor. An approach using a single cancer factor associated with a  was limited in increasing the diagnostic accuracy to over 90%. However, to overcome this limitation, the team simultaneously used different kinds of cancer factors instead of using only one to enhance the  innovatively.

The team developed an ultrasensitive semiconductor sensor system capable of simultaneously measuring trace amounts of four selected cancer factors in urine for diagnosing prostate cancer. They trained AI by using the correlation between the four cancer factors, which were obtained from the developed sensor. The trained AI algorithm was then used to identify those with prostate cancer by analyzing complex patterns of the detected signals. The diagnosis of prostate cancer by utilizing the AI analysis successfully detected 76 urinary samples with almost 100 percent accuracy.

"For patients who need surgery and/or treatments, cancer will be diagnosed with high accuracy by using urine to minimize unnecessary biopsy and treatments, which can dramatically reduce  and medical staff's fatigue," Professor Jeong at Asan Medical Center said. "This research developed a smart biosensor that can rapidly diagnose prostate cancer with almost 100 percent accuracy only through a urine test, and it can be further used in the precise diagnoses of other cancers via a urine test," Dr. Lee at the KIST said.


More information: Hojun Kim et al, Noninvasive Precision Screening of Prostate Cancer by Urinary Multimarker Sensor and Artificial Intelligence Analysis, ACS Nano (2020). DOI: 10.1021/acsnano.0c06946
Journal information: ACS Nano 


Provided by National Research Council of Science & Technology

Читайте также:

Десять лучших систем здравоохранения мира

редакция журнала Новых Концепций обращает внимание читателей на то, что две лучшие медицины в мире - в бывших британских колониях, находящихся в орбите Китая

Ученые США приблизились к полному избавлению человечества от ВИЧ

Ученые в США разработали комплексный иммунотерапевтический подход к лечению ВИЧ, который позволяет не только обнаружить вирус, скрывающийся в иммунной системе больного, но и навсегда уничтожить его, а это первый шаг к созданию вакцины против ВИЧ.

Китайский ученый получил три года за коррекцию генома эмбрионов, в результате которой родились двое детей с иммунитетом к ВИЧ

Суд города Шэньчжэня приговорил китайского ученого Хэ Цзянькуя к трем годам тюрьмы и штрафу в 3 млн юаней (около 430 тыс. долларов) за проведение незаконного в Китае эксперимента с рождением детей из эмбрионов с отредактированным геномом.

Older people have become younger: physical and cognitive function have improved meaningfully in 30 years

The functional ability of older people is nowadays better when it is compared to that of people at the same age three decades ago. This was observed in a study conducted at the Faculty of Sport and Health Sciences at the University of Jyväskylä, Finland.

Добавить комментарий

Оставлять комментарии могут только зарегистрированные пользователи.
Войдите в систему используя свою учетную запись на сайте:
Email: Пароль:

напомнить пароль